What are the Adverse Events?

 

Your patient with Chronic Kidney Disease is experiencing pruritus – is this symptom a known adverse event associated with their course of treatment?

What are the known adverse events for their course of treatment?

Outline

  • Review the known adverse events for a treatment.
  • Determine if the symptom your patient is experiencing is a known adverse event for their course of treatment.
  • Apply your knowledge and choose or change your patient’s course of treatment.
What Do You Need To Do?

Calibrate your knowledge of the adverse events associated with a certain treatment and review the known adverse events for treatments in the appropriate resources.

Apply this knowledge to choose or change the course of treatment.

 

Why Is This Important?

Reviewing the adverse events and drug interactions associated with a treatment will allow you to make better decisions about your patient’s course of treatment and change treatment plans if adverse events develop.

 

How Can You Make These Connections?

Take the following quiz to assess how much you know about the known adverse events for CKD treatments:

Take Quiz

Search the best resources to review the known adverse events:

Micromedex is a drug database with information about drug interactions, adverse events, and much more.

Lexicomp (Up-To-Date) is a subset of the Up-To-Date database specific to drug information such as drug interactions and adverse events.

If an adverse event for a treatment is not reported, search in PubMed Clinical Queries and Goodman and Gilman’s: The Pharmacological Basis of Therapeutics (available through Access Medicine) for less common adverse events.

 

Using the Resources

Micromedex

Select the Micromedex application (top right of screen). Enter your drug name in the main search bar.

Select the appropriate entry.

Use the menu on the left side of the screen to jump to the appropriate section: Dosing/Administration, Medication Safety, Mechanism of Action, Toxicology, etc.

Micromedex is available via mobile applications.

A tutorial and more information is available at Micromedex Solutions Help

 

Lexicomp (from Up-To-Date)

Enter the drug or disease name directly into the search bar or select the appropriate tab: Drug interactions, calculators, drug reports, toxicology, etc.

 

PubMed (Clinical Queries)

Access PubMed through the Library’s website, under the “Top Resources” heading – http://library.cumc.columbia.edu

On the main page, look for the “PubMed Tools” heading on the middle lower portion of the screen. Click “clinical queries”.

Enter your search terms using the appropriate Boolean operators. The results will appear in three columns: we are interested in the middle column, the Systematic Reviews.

Search in this section for appropriate systematic reviews that have been written about your topic.

 

Access Medicine

Enter your term in the main search bar – can be the full term or an acronym (can search for “chronic kidney disease” or “CKD”).

There are possibilities to narrow your search by textbook or topic (left hand side of results screen). You can also limit by publication category: books, quick reference, multimedia, images, cases, or patient education.

Access Medicine is available via mobile applications.

 

Note: Try searching in Micromedex and Lexicomp to see which you prefer using.

For more information please visit the Learning at Your Own Pace tutorials page on the library website – http://library.cumc.columbia.edu/learning-your-pace-tutorials

Review The Important Concepts

The following review activity will test your knowledge of CKD adverse events and the information you learned about in this section:

CKD Adverse Events Review Activity

Summary

Question yourself! The best way to calibrate how much you know about the adverse events is to ask yourself questions.

Always double check your knowledge! Look for information about the known adverse events in Micromedex or Lexicomp. If there are no known adverse events reported, search in PubMed or the Goodman and Gilman Textbook for lesser known or rare adverse events.

Apply the knowledge you found to your unique patient and current clinical context. Make your best decision based on the information you found and your medical training.